Najafov Lab

Hyunjin Noh, Ph.D.

Postdoc

Education and Training

B.S. Microbiology. PUSAN NATIONAL UNIVERSITY, Pusan, Republic of Korea

Ph.D. Biomedical Science. AJOU UNIVERSITY SCHOOL OF MEDICINE, Suwon, Republic of Korea
• Field: Cell Biology, Molecular Biology, and Necroptosis
• Mentor: You-Sun Kim, Ph.D.

In the Najafov Lab, my research focuses on molecular mechanisms of necroptosis, one form of immunogenic cell death, and their implications in disease pathogenesis. My current interest lies in elucidating fundamental mechanisms to regulate necroptosis via key protein modification by metabolites that control the cell death and regulate immune response.

Awards and Honors

• 2023 University President’s Award, Ajou University
• 2020 Listed "People Who Enhanced Korea's International Fame" section, Biological Research Information Center (BRIC)

Publications

1. Choi, J.I.; Cho, E.J.; Yang, M.J.; Noh, H.J.; Park, S.H.; Kim, S.; Kim, Y.S.; Sung, C.O.; Lee, D. Hypoxic microenvironment determines the phenotypic plasticity and spatial distribution of cancer-associated fibroblasts, Clin Transl Med. 2023 Oct; 13(10): e1438.

2. Hwang, S.M.; Ha, Y.J.; Koo, G.B.; Noh, H.J.; Lee, A.Y.; Kim, B.J.; Hong, S.M.; Morgan, M.J.; Eyun, S.I.; Lee, D.; Roe, J.S.; Lee, Y.; Kim, Y.S. LCK-Mediated RIPK3 Activation Controls Double-Positive Thymocyte Proliferation and Restrains Thymic Lymphoma by Regulating the PP2A-ERK Axis, Adv Sci. 2022 Nov;9(32):e2204522. doi:10.1002/advs.202204522. Epub 2022 Sep 25. PubMed PMID: 36161785

3. Jeon, J.*; Noh, H.J.*; Lee, H.; Park, H.H.; Ha, Y.J.; Park, S.H.; Lee, H.; Kim, S.J.; Kang, H.C.; Eyun, S.I.; Yang, S.; Kim, Y.S. TRIM24-RIP3 axis perturbation accelerates osteoarthritis pathogenesis. Ann Rheum Dis. 2020 Sep 7; annrheumdis-2020-217904. (*These authors contributed equally)

4. Kim, Y.S.; Noh, H.J.; Yoo, I.; Lee, D. Androgen Receptor is Mostly Not Expressed in Gastric Cancers. Appl Immunohistochem Mol Morphol. 2020 Feb;28(2):e17-e18

5. Kang, Y.P.; Yoon, J.H.; Long, N.P.; Koo, G.B.; Noh, H.J.; Oh, S.J.; Lee, S.B.; Kim, H.M.; Hong, J.Y.; Lee, W.J.; Lee, S.J.; Hong, S.S.; Kwon, S.W.; Kim, Y.S. Spheroid-Induced Epithelial-Mesenchymal Transition Provokes Global Alterations of Breast Cancer Lipidome: A Multi-Layered Omics Analysis. Front Oncol. 2019 Mar 21;9:145.

6. Park, H.H.; Choi, S.W.; Lee, G.J.; Kim, Y.D.; Noh, H.J.; Oh, S.J.; Yoo, I.; Ha, Y.J.; Koo, G.B.; Hong, S.S.; Kwon, S.W.; Kim, Y.S. A formulated red ginseng extract inhibits autophagic flux and sensitizes to doxorubicin-induced cell death. J Ginseng Res. 2019 Jan;43(1):86-94

7. Choi, S.W.; Park, H.H.; Kim, S.; Chung, J.M.; Noh, H.J.; Kim, S.K.; Song, H.K.; Lee, C.W.; Morgan, M.J.; Kang, H.C.; Kim, Y.S. PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation. Mol Cell. 2018 Jun 7;70(5):920-935.e7

8. Kim, H.A.; Han, J.H.; Kim, W.J.; Noh, H.J.; An, J.M.; Yim, H.; Jung, J.Y.; Kim, Y.S.; Suh, C.H. TLR4 Endogenous Ligand S100A8/A9 Levels in Adult-Onset Still's Disease and Their Association with Disease Activity and Clinical Manifestations. Int J Mol Sci. 2016 Aug 16;17(8):1342.

9. Jung, B.; Kang, H.; Lee, W.; Noh, H.J.; Kim, Y.S.; Han, M.S.; Baek, M.C.; Kim, J.; Bae, J.S. Anti-septic effects of dabrafenib on HMGB1-mediated inflammatory responses. BMB Rep. 2016 Apr;49(4):214-9.