Shehreen Amjad, Ph.D.
PostdocEducation and Training
Bachelor’s in Bioinformatics, Comsats Institute of Information and Technology (Islamabad, Pakistan)
Masters & Ph.D. integrated in Animal Science and Technology, Chung Ang University (Anseong South Korea)
In the Najafov Lab, my focus is on molecular and signaling pathways involved in necroptosis. My previous research was focused on the impact of various phthalate combinations on male fertility, focusing on sperm receptors and to conduct multigenerational and transgenerational studies on the impact of phthalates and BPA on male mice. My findings highlighted specific mechanisms and pathways through which these environmental pollutants influence sperm function. Additionally, the transgenerational study suggested that the impact may be transmitted through epigenetic changes (DNA methylation) rather than direct alterations in the DNA sequence. My PhD work contributed to our understanding of the reproductive effects of common environmental pollutants on male fertility.
Publications
1. Amjad, S, Rahman, M. S., Pang, W. K., Ryu, D. Y., Adegoke, E. O., Park, Y. J., & Pang, M. G. (2021). Effects of phthalates on the functions and fertility of mouse spermatozoa. Toxicology, 454, 152746. Advance online publication. https://doi.org/10.1016/j.tox.2021.152746 IF: 4.1
2. Amjad, S, Rahman, M. S., & Pang, M. G. (2020). Role of Antioxidants in Alleviating Bisphenol A Toxicity. Biomolecules, 10(8), 1105. https://doi.org/10.3390/biom10081105 IF: 4.694
3. Adegoke E. O., Rahman M.S., Amjad, S, Pang WK, Ryu DY, Park YJ, Pang MG. Bisphenol A damages testicular junctional proteins transgenerationally in mice. Environ Pollut. 2022 Jun 1;302:119067. doi: 10.1016/j.envpol.2022.119067. Epub 2022 Feb 26. PMID: 35231543. IF: 8.071
4. Rahman, M. S., Pang, W.K., Amjad, S, Ryu, D. Y., Adegoke, E. O., Park, Y.J., Pang, M. G. (2022). Hepatic consequences of a mixture of endocrine-disrupting chemicals in male mice, Journal of Hazardous Materials,Volume 436, 2022, https://doi.org/10.1016/j.jhazmat.2022.129236. IF: 10.588
5. Park YJ, Rahman MS, Pang WK, Ryu DY, Jung MJ, Amjad, S, Kim JM, Pang MG. Systematic multi-omics reveals the overactivation of T cell receptor signaling in immune system following bisphenol A exposure. Environ Pollut. 2022 Sep 1;308:119590. doi:10.1016/j.envpol.2022.119590. Epub 2022 Jun 22. PMID: 35752395.
6. Pang, W. K., Amjad, S, Ryu, D. Y., Adegoke, E. O., Rahman, M. S., Park, Y. J., & Pang, M. G. (2022). Establishment of a male fertility prediction model with sperm RNA markers in pigs as a translational animal model. Journal of animal science and biotechnology, 13(1), 84. https://doi.org/10.1186/s40104-022-00729-9
7. Sadiq, I., Zulfiqar, M., Maryam, A., Rehman, K., Noreen, S., Mursalin, M., Amjad, S ... & Siddiqi, A. R. (2018). Insilico studies of CBL-CIPK signaling in rice: response against hypoxia is triggered by interaction of cbl10 with CIPK15. Pak. J. Bot, 50(4), 1407-1413. IF: 0.